
As the 2025 MLB season kicks off, all eyes turn to Tokyo, Japan, where the Los Angeles Dodgers and Chicago Cubs will ignite the annual Tokyo Series. This high-stakes game not only signals the start of another thrilling baseball season but also marks a significant moment in sports, being broadcast across continents from the iconic Tokyo Dome.

A Historic Opening in Tokyo
On Tuesday, March 18, at the crack of dawn for American viewers, the Dodgers and Cubs will face off in a game that promises more than just regular season baseball—it offers a glimpse into the potential dynamics of MLB’s international influence. The first pitch is set for 6:10 a.m. ET, with live coverage on FOX, SportsNet LA, and Marquee Sports Network.
Betting Odds and Key Predictions
The Dodgers enter the game as favorites, with odds set at -160 on the moneyline, according to BetMGM. Meanwhile, the Cubs, not far behind, are listed as +135 underdogs. The game’s over/under stands at 8 runs, reflecting expectations of a tightly contested match. For those looking at the run lines, the Dodgers are +105 to cover -1.5, while the Cubs are -125 to stay within 1.5 runs.
Expert Picks and Insights
My analysis points to potential value in backing the Cubs on the moneyline at +135, and favoring an over 7.5 runs scenario for the game’s total score. These picks hinge on a detailed evaluation of both teams’ current rosters and recent performances, suggesting that the Cubs might just edge out an upset, while a high-scoring affair could be on the cards.
Key Players and Matchup Dynamics
Pitching Prowess on Display
This game is notable for featuring a historic matchup between Yoshinobu Yamamoto and Shota Imanaga—two of Japan’s finest pitchers, making this the first MLB season opener started by Japanese pitchers. Yamamoto, a three-time Sawamura Award winner, and Imanaga, a standout performer in last year’s MLB, bring an exciting element to the game, highlighting the depth of pitching talent coming out of Japan.

Impact of Player Absences
The Dodgers will feel the absence of Mookie Betts, sidelined due to illness, along with several key relievers. This setback could level the playing field somewhat, especially with the Cubs also missing their regular second baseman, Nico Hoerner. These injuries could play a crucial role in the game’s outcome, impacting both team strategies and individual performances.
Defensive and Offensive Comparisons
From a defensive standpoint, the Cubs boast strong up-the-middle security with players like Dansby Swanson and Pete Crow-Armstrong, who bring exceptional defensive skills to the field. Offensively, while the Dodgers typically have a robust lineup, the absence of Betts might hinder their usual firepower, potentially giving the Cubs an edge in this matchup.
Tokyo Dome: A Unique Venue
The Tokyo Dome, with its distinct dimensions and playing conditions, adds an extra layer of intrigue to this opening series. Known for favoring certain types of hits due to its unique structure, players might adjust their tactics to capitalize on the park’s characteristics, particularly in terms of power hitting and fly-ball tendencies.
Prop Bets and Player Performances
Given the specific conditions at the Tokyo Dome, certain players like Kyle Tucker and Will Smith could have advantageous odds in prop bets, especially for hitting home runs or doubles. The game’s setting provides a unique opportunity for bettors and fans to engage with these nuanced aspects of baseball analytics.

As we gear up for this exhilarating start to the MLB season, the Tokyo Series between the Dodgers and Cubs is more than just a game—it’s a celebration of international baseball, a showcase of top pitching talent, and a test of strategic depth. With all factors considered, this opener is not only a must-watch for baseball enthusiasts but also a significant event for sports bettors looking to capitalize on early season dynamics. Don’t miss this clash of titans at the Tokyo Dome, a fitting venue for what could be one of the most memorable games of the season.